In enzymology, a 2,3-dihydroxyindole 2,3-dioxygenase (EC 1.13.11.23) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxyindole O2 ⇌ {\displaystyle \rightleftharpoons } anthranilate CO2

Thus, the two substrates of this enzyme are 2,3-dihydroxyindole and O2, whereas its two products are anthranilate and CO2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing). This enzyme participates in tryptophan metabolism.

References

  • Fujioka M, Wada H (1968). "The bacterial oxidation of indole". Biochim. Biophys. Acta. 158 (1): 70–8. doi:10.1016/0304-4165(68)90073-1. PMID 5652436.

Synthesis of 3,3′dihydroxy2,2′diindan1,1′dione derivatives for

Comparison of biphenyl 2,3dioxygenase active site to other Rieske

Synthesis of 3,3′dihydroxy2,2′diindan1,1′dione derivatives for

[PDF] Synthesis of mechanism probes and potential inhibitors for

Diastereoselective synthesis of trans 2,3dihydroindoles via formal [4