Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

Function

UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene de-repression, a potential means of regulating cellular metabolism.

References

Further reading



UTX1 expression and utx1 embryonic phenotypes. (A) Top Human UTX and

UTX (gene) Wikipedia

UTX occupies the promoters of iNKT cell signature genes that exhibit

Gene expression profiling analysis of UTXregulated genes using

UTX binding correlates with promotion and suppression of gene